CV. ADHI JAYA

Perusahaan CV. ADHI JAYA

Sweet’s Syndrome

Sweet’s syndrome is a neutrophilic dermatosis. Sweet’s syndrome (SS) is an uncommon, recurrent skin disease characterized by painful plaque-forming inflammatory papules and associated with fever, arthralgia, and peripheral leukocytosis.

Causes of Sweet’s Disease

* Upper respiratory tract infection (e.g. chest infection, streptococcal throat infection)
* Vaccination
* Inflammatory bowel disease (e.g. ulcerative colitis or Crohn’s disease)

Signs and symptoms of Sweet’s Disease

Prodromes are febrile upper respiratory tract infections. GI symptoms (diarrhea), tonsillitis, influenza-like illness, 1 to 3 weeks before skin lesions. Lesions tender/painful. Skin lesions Bright red, smooth, tender papules (2 to 4 mm in diameter) that coalesce to form irregular, sharply bordered, inflammatory plaques. If associated with leukemia, bullous lesions may occur, and lesions may mimic pyoderma gangrenosum. May present as a single lesion or multiple lesions, asymmetrically distributed. What causes Sweet disease?

* Upper respiratory tract infection (e.g. chest infection, streptococcal throat infection)
* Inflammatory bowel disease (e.g. ulcerative colitis or Crohn disease)
Sweet disease generally results in the following symptoms:

Investigations

* Raised white cell count (neutrophil leukocytosis)
* Numerous polynuclear neutrophil inflammatory cells on skin biopsy associated with broken-up neutrophils (leukocytoclasia) and swelling of cells lining blood vessels (endothelial cells)

Other neutrophilic dermatoses (skin conditions characterised by neutrophils) include pyoderma gangrenosum, neutrophilic eccrine hidradenitis, erythema elevatum diutinum and Behcet disease.

Occasionally Sweet syndrome is the presenting sign of a serious blood condition.

Filed under: Lyme Disease, ,

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